The natural history of severe asthma and influences of early risk factors: a population-based cohort study

Authors: Chen W, Marra CA, Lynd LD, FitzGerald JM, Zafari Z, Sadatsafavi M Background: Severe asthma is associated with disproportionately high morbidity, but little is known about its natural history and how risk factors at first year of diagnosis modify its subsequent development. Methods: Using administrative health data, we retrospectively followed patients 14-55 years of age […]

The global economic burden of chronic respiratory diseases

Authors: Ehteshami-Afshar S, FitzGerald JM, Doyle-Waters MM, Sadatsafavi M Abstract Non-communicable diseases are now the number one cause of disabilities and loss of life expectancy. Among them, chronic respiratory conditions constitute a major class. The burden of chronic respiratory diseases is generally increasing across the globe and asthma and chronic obstructive pulmonary disease (COPD) are among […]

The additional burden of comorbidity along with asthma control on health-related quality of life in asthma

Authors: Chen W, Lynd L, FitzGerald JM, Marra C, Rousseau R, Sadatsafavi M Purpose: To examine the effect of comorbidities on health-related quality of life (HRQoL) and their interaction with asthma control. Methods: In a random sample of adults with asthma, we measured generic (EQ5D) and disease-specific (AQ5D) utility scores. Asthma symptom control was determined […]

Assessing beliefs and risk perceptions on smoking and smoking cessation in immigrant Chinese adult smokers residing in Vancouver, Canada: a cross-sectional study

Authors: FitzGerald JM, Poureslami I, Shum J OBJECTIVES: We aimed to conduct culturally-based participatory research to assess cultural and belief contexts for smoking behaviours within Mandarin and Cantonese communities. Outcome variables were smoking-related knowledge, smoking patterns, attitudes and beliefs, and perceived barriers and facilitators to successful cessation. DESIGN: A community-based approach was applied involving smokers, […]

Cost-effectiveness of bronchial thermoplasty, omalizumab, and standard therapy for moderate-to-severe allergic asthma

Authors: Zafari Z, Sadatsafavi M, Marra C, Chen W, FitzGerald JM Background: Bronchial thermoplasty (BT) is a recently developed treatment for patients with severe uncontrolled asthma. Whilst studies have suggested the health benefits of this intervention, no study has evaluated its cost-effectiveness. BT can be an alternative to ongoing maintenance therapy (standard therapy) or omalizumab […]

Interaction effect of psychological distress and asthma control on productivity loss in patients with asthma: a population-based study

Authors: Moullec G, FitzGerald JM, Rousseau R, Chen W, Sadatsafavi M, Economic Burden of Asthma (EBA) study team Background: Little is known about the potential synergistic effect of comorbid psychological distress (PD) and uncontrolled asthma (UA) on productivity loss. We estimated the productivity loss associated with the combination of these two potentially preventable conditions in […]

Quality of life and asthma symptom control: room for improvement in care and measurement

Authors: Sadatsafavi M, McTaggart-Cowan H, Chen W, FitzGerald JM, Economic Burden of Asthma (EBA) Study Group Background: The recent Global Initiative for Asthma (GINA) recommends achieving symptom control and minimizing the future risk of poor outcomes as priorities for asthma management. Objective: To quantify the association between symptom control and quality of life in asthma. Methods: […]

Incorporating external evidence in trial-based cost-effectiveness analysis: the use of resampling methods

Authors: Sadatsafavi M, Marra C, Aaron S, Bryan S Background: Cost-effectiveness analyses (CEAs) that use patient-specific data from a randomized controlled trial (RCT) are popular, yet such CEAs are criticized because they neglect to incorporate evidence external to the trial. A popular method for quantifying uncertainty in a RCT-based CEA is the bootstrap. The objective […]

The impact of incorporating Bayesian network meta-analysis in cost-effectiveness analysis – a case study of pharmacotherapies for moderate to severe COPD

Authors: Thorlund K, Zafari Z, Druyts E, Mills EJ, Sadatsafavi M Background: To evaluate the impact of using network meta-analysis (NMA) versus pair wise meta-analyses (PMA) for evidence synthesis on key outputs of cost-effectiveness analysis (CEA). Methods: We conducted Bayesian NMA of randomized clinical trials providing head-to-head and placebo comparisons of the effect of pharmacotherapies […]

Heterogeneity’s ruses: the neglected role of between-individual variability in longitudinal studies of COPD exacerbations

Authors: Sadatsafavi M and FitzGerald JM Studying the causal and temporal association between past and future exacerbations in COPD is an active area of research. Standard survival analysis techniques often used in such studies typically produce results that pertain to the overall population, whereas the greatest interest is in the study of associations within individuals. […]