THE UNIVERSITY OF BRITISH COLUMBIA
METHODOLOGY: PRECISION MEDICINE / CLINICAL PREDICTION MODELLING
Validation and Utility Testing of Clinical Prediction Models: Time to Change the Approach
JAMA. 2020 Jul 21;324(3):235-236
Testing Clinical Prediction Models—Reply
We agree with Drs Goldstein and Pencina about the necessity of adapting risk models to the clinical use case. We share their vision that a cloud-based platform does not have to be centralized; each practitioner will set up their own environment for the mod...
We agree with Drs Goldstein and Pencina about the necessity of adapting risk models to the clinical use case. We share their vis...
Should the number of acute exacerbations in the previous year be used to guide treatments in COPD?
Eur Respir J. 2020 Aug 27;2002122. doi: 10.1183/13993003.02122-2020.
The Acute COPD Exacerbation Prediction Tool (ACCEPT): a modelling study
This Lancet Respiratory Medicine describes a new prediction model to predict COPD exacerbations using simple clinical predictors
A Threshold-Free Summary Index for Quantifying the Capacity of Covariates to Yield Efficient Treatment Rules
Statistic in Medicine. 2020;10.1002/sim.8481
The association between rate and severity of exacerbations in chronic obstructive pulmonary disease: an application of a joint frailty-logistic model
Am J Epidemiol. 2016;184(9):681–689
Individualized prediction of lung-function decline in chronic obstructive pulmonary disease
The diagnostic performance of patient symptoms in screening for COPD
Respir Res. 2018 Feb 7;19(1):26
Relative Impact Characteristic (RIC) curve: a graphical tool to visualize and quantify the clinical utility and population-level consequences of implementing markers
Ann Epidemiol. 2018 Oct;28(10):717-723.e3
Predicting severe COPD exacerbations: A population surveillance approach with administrative data
An individualized prediction model for long-term lung function trajectory and risk of COPD in the general population
Chest. 2019 Sep 19. pii: S0012-3692(19)33868-1
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Studies based on administrative or other real world data
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Describes the main theme used (Asthma, COPD, methodological research).
Our funded studies and associated research output