THE UNIVERSITY OF BRITISH COLUMBIA
Validation and Utility Testing of Clinical Prediction Models: Time to Change the Approach
For millennia, humans have developed their desired phenotypic traits in plants/animals by giving a survival advantage to those who possessed them. What if a “survival advantage” could be given to predictive models that perform better?”
For millennia, humans have developed their desired phenotypic traits in plants/animals by giving a survival advantage to those w...
A Threshold-Free Summary Index for Quantifying the Capacity of Covariates to Yield Efficient Treatment Rules
Statistic in Medicine. 2020;10.1002/sim.8481
The association between rate and severity of exacerbations in chronic obstructive pulmonary disease: an application of a joint frailty-logistic model
Am J Epidemiol. 2016;184(9):681–689
Relative Impact Characteristic (RIC) curve: a graphical tool to visualize and quantify the clinical utility and population-level consequences of implementing markers
Ann Epidemiol. 2018 Oct;28(10):717-723.e3
Network vs. Pairwise Meta-Analyses: A Case Study of the Impact of an Evidence-Synthesis Paradigm on Value of Information Outcome
Pharmacoeconomics. 2014 Oct;32(10):995-1004
A statistical method was used for the meta-analysis of tests for latent TB in the absence of a gold standard, combining random-effect and latent-class methods to estimate test accuracy
J Clin Epidemiol. 2010 Mar;63(3):257-69
Incorporating external evidence in trial-based cost-effectiveness analysis: the use of resampling methods
Trials. 2014 Jun 3;15:201
The impact of incorporating Bayesian network meta-analysis in cost-effectiveness analysis – a case study of pharmacotherapies for moderate to severe COPD
Cost Eff Resour Alloc. 2014 Mar 13;12(1):8
Two-level resampling as a novel method for calculation of the expected value of sample information in economic trials
Health Econ. 2013 Jul;22(7):877-82
A Quantitative Benefit-Risk Analysis of Isoniazid for Treatment of Latent Tuberculosis Infection Using Incremental Benefit Framework
Value Health. 2013 Jan-Feb;16(1):66-75
Need for speed: an efficient algorithm for calculation of single-parameter expected value of partial perfect information
Value Health. 2013;16(2):438–448
Lowering the P Value Threshold
Lowering the #pvalue threshold for phase 3 RCTs is inappropriate, as high prior probability of replication (68%) leads to high positive predictive values (97%) when p=0.05
Lowering the #pvalue threshold for phase 3 RCTs is inappropriate, as high prior probability of replication (68%) leads to high p...
The “Lost NNT” can be used to represent uncertainty surrounding number needed to treat
Currently, confidence interval is the standard way of communicating uncertainty around the number needed to treat (NNT). But the CI is not directly relevant to the treatment decision.Uncertainty around treatment only matters because it may result in the ch...
Currently, confidence interval is the standard way of communicating uncertainty around the number needed to treat (NNT). But the...
Should the number of acute exacerbations in the previous year be used to guide treatments in COPD?
Eur Respir J. 2020 Aug 27;2002122. doi: 10.1183/13993003.02122-2020.
Heterogeneity’s ruses: the neglected role of between-individual variability in longitudinal studies of COPD exacerbations
Thorax. 2014 Nov;69(11):1043-4
The association between previous and future severe exacerbations of chronic obstructive pulmonary disease: Updating the literature using robust statistical methodology.
Using robust statistical methodology that controlled for heterogeneity in exacerbation rates among individuals, we demonstrated potential causal associations among past and future severe exacerbations, albeit the magnitude of association was noticeably low...
Using robust statistical methodology that controlled for heterogeneity in exacerbation rates among individuals, we demonstrated...
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