RESP

                        The economics of precision health: preventing air pollution-induced exacerbation in asthma
                      

The demonstrable value of precision medicine, in the context of common environmental exposures, has scarcely been explored. This study evaluated the cost effectiveness of a preventive personalised intervention to reduce the adverse effect of air pollution...

The demonstrable value of precision medicine, in the context of common environmental exposures, has scarcely been explored. This...

                        Model-Based ROC Curve: Examining the Effect of Case Mix and Model Calibration on the ROC Plot
                      

Medical Decision Making. October 2021. doi:10.1177/0272989X211050909

                        Trends in oral corticosteroids use in severe asthma: a 14-year population-based study
                      

Respir Res. 2021 Apr 9;22(1):103. doi: 10.1186/s12931-021-01696-x

                        Moving beyond AUC: decision curve analysis for quantifying net benefit of risk prediction models
                      

Eur Respir J. 2021 Sep 9:2101186. doi: 10.1183/13993003.01186-2021

                        The cost-effectiveness of as-needed budesonide-formoterol versus low-dose inhaled corticosteroid maintenance therapy in patients with mild asthma in Canada 
                      

Allergy Asthma Clin Immunol. 2021 Oct 12;17(1):108. doi: 10.1186/s13223-021-00610-w. PMID: 34641954.

                        Development and validation of the Evaluation Platform In COPD (EPIC): a population-based outcomes model of COPD for Canada
                      

Med Decis Making. 2019 Feb;39(2):152-16

                        Validation and Utility Testing of Clinical Prediction Models: Time to Change the Approach
                      

JAMA. 2020 Jul 21;324(3):235-236

Testing Clinical Prediction Models—Reply

We agree with Drs Goldstein and Pencina about the necessity of adapting risk models to the clinical use case. We share their vision that a cloud-based platform does not have to be centralized; each practitioner will set up their own environment for the mod...

We agree with Drs Goldstein and Pencina about the necessity of adapting risk models to the clinical use case. We share their vis...

International severe asthma registry (ISAR): protocol for a global registry

The International Severe Asthma Registry (ISAR) is a collaborative initiative comprising existing and new registries that builds on data from multiple nations and regions and increases the statistical power and comparability of data. It is the first global...

The International Severe Asthma Registry (ISAR) is a collaborative initiative comprising existing and new registries that builds...

                        Understanding resource utilization and mortality in COPD to support policy making: A microsimulation study
                      

The aim of this study is to develop a platform that allows: 1) policymakers to identify subgroups of the COPD population that are at increased risk of emergency department visits, hospitalization and mortality and 2) health economists to obtain input or va...

The aim of this study is to develop a platform that allows: 1) policymakers to identify subgroups of the COPD population that ar...

                        The Long-Term Burden of COPD Exacerbations During Maintenance Therapy and Lung Function Decline
                      

There is sparse evidence that COPD exacerbations are associated with subsequent accelerated lung function decline, particularly in those with mild disease. Lung function decline is most accelerated at the early stages of COPD, and early identification of p...

There is sparse evidence that COPD exacerbations are associated with subsequent accelerated lung function decline, particularly...

                        Should the number of acute exacerbations in the previous year be used to guide treatments in COPD?
                      

Eur Respir J. 2020 Aug 27;2002122. doi: 10.1183/13993003.02122-2020.

                        Predicting Severe COPD Exacerbations: Developing a Population Surveillance Approach with Administrative Data
                      

Ann Am Thorac Soc. 2020 May 8.

                        Statin use and lung cancer risk in chronic obstructive pulmonary disease patients: a population-based cohort study
                      

Respir Res. 2020 May 19;21(1):118

                        The cost-effectiveness of as-needed budesonide/formoterol versus low-dose inhaled corticosteroid maintenance therapy in patients with mild asthma in the UK
                      

Respiratory Medicine, 2020 (171); 106079

                        Pharmacologic Management of Chronic Obstructive Pulmonary Disease. An Official American Thoracic Society Clinical Practice Guideline
                      

The purpose of this clinical practice guideline is to address specific clinically important questions regarding the pharmacologic management of COPD. The expert panel, in collaboration with a team of methodologists, prioritized and developed six questions...

The purpose of this clinical practice guideline is to address specific clinically important questions regarding the pharmacologi...

The Acute COPD Exacerbation Prediction Tool (ACCEPT): a modelling study

This Lancet Respiratory Medicine describes a new prediction model to predict COPD exacerbations using simple clinical predictors

                        A Threshold-Free Summary Index for Quantifying the Capacity of Covariates to Yield Efficient Treatment Rules
                      

Statistic in Medicine. 2020;10.1002/sim.8481

Looking at the COPD spectrum through “PRISm”

A comment on the study "Preserved ratio impaired spirometry (PRISm) is a prevalent, neglected condition whose prognosis is close to that of COPD" by Wijnant et al. Given that PRISm resembles COPD in term of reduction in FEV1, but not in terms of FEV1/FVC r...

A comment on the study "Preserved ratio impaired spirometry (PRISm) is a prevalent, neglected condition whose prognosis is close...

                        Cost-effectiveness of Implementing Objective Diagnostic Verification of Asthma in the United States 
                      

J Allergy Clin Immunol. 2019;S0091-6749(19)31634-3

                        The association between rate and severity of exacerbations in chronic obstructive pulmonary disease: an application of a joint frailty-logistic model
                      

Am J Epidemiol. 2016;184(9):681–689

                        Individualized prediction of lung-function decline in chronic obstructive pulmonary disease
                      

CMAJ. 2016;188(14):1004–1011

                        The Impact of Care Specialty on Survival-Adjusted Medical Costs of COPD Patients After a Hospitalization: a longitudinal analysis.
                      

J Gen Intern Med. 2018 Sep;33(9):1528-1535

                        Stability of asthma symptom control in a longitudinal study of mild–moderate asthmatics
                      

J Allergy Clin Immunol Pract. 2017 Nov - Dec;5(6):1663-1670.e5

                        Complementary and alternative asthma treatments and their association with asthma control: a population-based study
                      

BMJ Open. 2013 Sep 4;3(9):e003360

                        History of Asthma in Patients with Chronic Obstructive Pulmonary Disease: A Comparative Study of Economic Burden.
                      

Ann Am Thorac Soc. 2016 Feb;13(2):188-96

                        The preventable burden of productivity loss due to suboptimal asthma control: a population-based study
                      

Chest. 2014 Apr;145(4):787-793

The impact of comorbidities on productivity loss in asthma patients

Respir Res. 2016 Aug 26;17(1):106

                        Long-term effects of inhaled corticosteroids on bone mineral density in older women with asthma or COPD: a registry-based cohort study
                      

Arch Osteoporos. 2018 Oct 29;13(1):116

                        A systematic review of the adverse events and economic impact associated with oral corticosteroids in asthma
                      

J Asthma. 2019 Dec;56(12):1334-1346

                        Asthma is not associated with the need for surgery in Crohn’s disease when controlling for smoking status: a population-based cohort study. 
                      

Clin Epidemiol. 2018 Jul 12;10:831-840

The diagnostic performance of patient symptoms in screening for COPD

Respir Res. 2018 Feb 7;19(1):26

                        Characterizing undiagnosed chronic obstructive pulmonary disease: a systematic review and meta-analysis
                      

Respir Res. 2018 Feb 7;19(1):26

                        Cost-effectiveness of tiotropium versus omalizumab for uncontrolled allergic asthma in US
                      

Cost Eff Resour Alloc. 2018 Jan 30;16:3

The importance of measuring asthma control in emerging economies.

Int J Tuberc Lung Dis. 2014 Mar;18(3):254

                        The projected economic and health burden of sub-optimal asthma control in Canada
                      

Respir Med. 2018 May;138:7-12

                        Relative Impact Characteristic (RIC) curve: a graphical tool to visualize and quantify the clinical utility and population-level consequences of implementing markers
                      

Ann Epidemiol. 2018 Oct;28(10):717-723.e3

                        Network vs. Pairwise Meta-Analyses: A Case Study of the Impact of an Evidence-Synthesis Paradigm on Value of Information Outcome
                      

Pharmacoeconomics. 2014 Oct;32(10):995-1004

COPD: undefeated!

Chest. 2015 Apr;147(4):868-869

The global economic burden of asthma and chronic obstructive pulmonary disease

Int J Tuberc Lung Dis. 2016 Jan;20(1):11-23

                        Future impact of various interventions on the burden of COPD in Canada: a dynamic population model.
                      

PLoS One. 2012;7(10):e46746

                        Has asthma medication use caught up with the evidence? A 12-year population-based study of trends
                      

Chest. 2017 Mar;151(3):612-618

                        Predictors of inappropriate usage of reliever medications in asthma: a 12-year population-based study
                      

BMC Pulm Med. 2018 Feb 12;18(1):33.

                        Dispensation of long-acting β agonists with or without inhaled corticosteroids, and risk of asthma-related hospitalisation: a population-based study
                      

Thorax. 2014 Apr;69(4):328-34

                        Comparative outcomes of leukotriene receptor antagonists and long-acting β-agonists as add-on therapy in asthmatic patients: a population-based study
                      

J Allergy Clin Immunol. 2013 Jul;132(1):63-9

                        A statistical method was used for the meta-analysis of tests for latent TB in the absence of a gold standard, combining random-effect and latent-class methods to estimate test accuracy
                      

J Clin Epidemiol. 2010 Mar;63(3):257-69

                        Risk of cardiovascular comorbidity in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.
                      

Lancet Respir Med. 2015 Aug;3(8):631-9

                        Influences of Socioeconomic Status on Costs of Asthma Under Universal Health Coverage
                      

Med Care. 2016 Aug;54(8):789-95

Excess medical costs in patients with asthma and the role of comorbidity

Eur Respir J. 2016 Dec;48(6):1584-1592

Ten-year trends in direct costs of asthma: a population-based study

Allergy. 2017 Feb;72(2):291-299

                        Economic and health effect of full adherence to controller therapy in adults with uncontrolled asthma: A simulation study
                      

J Allergy Clin Immunol. 2014 Oct;134(4):908-915.e3

                        The Projected Epidemic Of COPD Hospitalizations Over the Next 15 Years: A Population Based Perspective
                      

Am J Respir Crit Care Med. 2017 Feb 1;195(3):287-291

                        The natural history of severe asthma and influences of early risk factors: a population-based cohort study
                      

Thorax. 2016 Mar;71(3):267-75

                        Cost-effectiveness of bronchial thermoplasty, omalizumab, and standard therapy for moderate-to-severe allergic asthma
                      

PLoS One. 2016 Jan 11;11(1):e0146003

                        Incorporating external evidence in trial-based cost-effectiveness analysis: the use of resampling methods
                      

Trials. 2014 Jun 3;15:201

                        The impact of incorporating Bayesian network meta-analysis in cost-effectiveness analysis – a case study of pharmacotherapies for moderate to severe COPD
                      

Cost Eff Resour Alloc. 2014 Mar 13;12(1):8

                        Two-level resampling as a novel method for calculation of the expected value of sample information in economic trials
                      

Health Econ. 2013 Jul;22(7):877-82

                        A Quantitative Benefit-Risk Analysis of Isoniazid for Treatment of Latent Tuberculosis Infection Using Incremental Benefit Framework
                      

Value Health. 2013 Jan-Feb;16(1):66-75

                        Excess economic burden of comorbidities in COPD: a 15-year population-based study
                      

Eur Respir J. 2017 Jul 27;50(1). pii: 1700393

The impact of inappropriate use of short acting beta agonists in asthma

Respir Med. 2017 Oct;131:135-140

                        Heterogeneity’s ruses: the neglected role of between-individual variability in longitudinal studies of COPD exacerbations
                      

Thorax. 2014 Nov;69(11):1043-4

                        One-year outcomes of inhaled controller therapies added to systemic corticosteroids after asthma-related hospital discharge
                      

Respir Med. 2015 Mar;109(3):320-8

Post-hospital syndrome in adults with asthma: a case-crossover study

Allergy Asthma Clin Immunol. 2013 Dec 23;9(1):49

                        Costs and health outcomes associated with primary versus secondary care after an asthma-related hospitalization, a population-based study
                      

Chest. 2013 Aug;144(2):428-435

Less chaos in the prognosis of asthma-chronic obstructive lung disease overlap.

Lancet Respir Med. 2016 Jun;4(6):421-2

                        A systematic review of health economics simulation models of chronic obstructive pulmonary disease
                      

Value Health. 2017;20(1):152–162

                        Need for speed: an efficient algorithm for calculation of single-parameter expected value of partial perfect information
                      

Value Health. 2013;16(2):438–448

                        The projected economic and health burden of uncontrolled asthma in the United States
                      

Am J Respir Crit Care Med. 2019 Nov 1;200(9):1102-111

                        An individualized prediction model for long-term lung function trajectory and risk of COPD in the general population 
                      

Chest. 2019 Sep 19. pii: S0012-3692(19)33868-1

                        The economic burden of multimorbidity in severe asthma patients: a 20-year population-based study 
                      

Thorax. 2019 Dec;74(12):1113-1119

                        Trends in prescriptions and costs of inhaled medications in chronic obstructive pulmonary disease: a 19-year population-based study from Canada
                      

Int J Chron Obstruct Pulmon Dis. 2019 Sep 3;14:2003-2013

                        Asthma control and productivity loss in those with work-related asthma: a population-based study
                      

The objectives of this study were to evaluate the associations between 1) asthma control and work-related asthma (WRA), 2) productivity loss and WRA/NWRA status and 3) productivity loss and WRA/non-work-related asthma (NWRA) status in individuals with the...

The objectives of this study were to evaluate the associations between 1) asthma control and work-related asthma (WRA), 2) produ...

                        Saving in medical costs by achieving guideline-based asthma symptom control: a population-based study
                      

This study aimed at informing an evidence gap in the literature. We have used a prospectively recruited sample, longitudinal evaluation of costs and control, and updated definitions of asthma control (according to the Global Initiative for Asthma [GINA] 20...

This study aimed at informing an evidence gap in the literature. We have used a prospectively recruited sample, longitudinal eva...

                        Empowering pharmacists in asthma management through interactive SMS (EmPhAsIS): study protocol for a randomized controlled trial.
                      

Previous studies have evaluated communication technologies in asthma care , but none of these studies have involved pharmacists.On the other hand, pharmacist-based studies on improving the management of asthma have hitherto used interventions whose real-wo...

Previous studies have evaluated communication technologies in asthma care , but none of these studies have involved pharmacists....

                        The additional burden of comorbidity along with asthma control on health-related quality of life in asthma
                      

Using a longitudinal random sample of adults with asthma, we explored the performance of both generic and asthma-specific HRQoL instruments to simultaneously distinguish between different levels of asthma control and changes in comorbidity status. Our prim...

Using a longitudinal random sample of adults with asthma, we explored the performance of both generic and asthma-specific HRQoL...

                        Quality of life and asthma symptom control: room for improvement in care and measurement
                      

The primary objective of this study was to quantify the gain in quality of life that can be achieved by achieving Global Initiative for Asthma (GINA) symptom control in patients with symptomatically uncontrolled or partially controlled asthma. We pursued s...

The primary objective of this study was to quantify the gain in quality of life that can be achieved by achieving Global Initiat...

                        Interaction effect of psychological distress and asthma control on productivity loss in patients with asthma: a population-based study
                      

The emphasis of asthma management is focussed on achieving current symptom control and the prevention of future risk. From this perspective, it is much more relevant to evaluate the interaction of asthma control and psychological distress (PD) in determini...

The emphasis of asthma management is focussed on achieving current symptom control and the prevention of future risk. From this...

                        The added effect of comorbidity on health-related quality of life in patients with asthma.
                      

Using a longitudinal random sample of adults with asthma, we explored the performance of both generic and asthma-specific HRQoL instruments to simultaneously distinguish between different levels of asthma control and changes in comorbidity status. Our prim...

Using a longitudinal random sample of adults with asthma, we explored the performance of both generic and asthma-specific HRQoL...

Triple therapy in a single inhaler: a new option for uncontrolled asthma

Commentary on Virchow et al. (Lancet. 2019, https://doi.org/10.1016/S0140-6736(19)32215-9)

Lowering the P Value Threshold

Lowering the #pvalue threshold for phase 3 RCTs is inappropriate, as high prior probability of replication (68%) leads to high positive predictive values (97%) when p=0.05

Lowering the #pvalue threshold for phase 3 RCTs is inappropriate, as high prior probability of replication (68%) leads to high p...

                        Long-Term Trajectories of Mild Asthma in Adulthood and Risk Factors of Progression
                      

Using administrative health data from a large province in Canada, we aimed to examine the long-term trajectory of mild asthma in adults older than 16 years and to identify demographic, clinical, and treatment-related factors during the earlier stages of di...

Using administrative health data from a large province in Canada, we aimed to examine the long-term trajectory of mild asthma in...

                        Long-term trajectories of mild asthma in adulthood and risk factors of progression 
                      

Using administrative health data from a large province of Canada, we aimed to examine the long-term trajectory of mild asthma in adults over 16 years and to identify demographic,clinical, and treatment-related factors during the earlier stages of disease t...

Using administrative health data from a large province of Canada, we aimed to examine the long-term trajectory of mild asthma in...

Modifiable factors associated with inappropriate use of asthma relievers

Identifying factors associated with inappropriate or excessive use of short-acting beta agonists (SABA) in asthma can help efforts towards safer use of such medications. We used British Columbian (BC)’s administrative health data to create a retrospective...

Identifying factors associated with inappropriate or excessive use of short-acting beta agonists (SABA) in asthma can help effor...

Ten-Year Trends in Direct Costs of COPD: A Population-Based Study.

Our primary objective in this study was to estimate the excess direct costs related to the care of patients with physician-diagnosed COPD from 2001 to 2010 in British Columbia. The secondary objectives were to evaluate the relative contributions of the var...

Our primary objective in this study was to estimate the excess direct costs related to the care of patients with physician-diagn...

Direct health care costs associated with asthma in British Columbia.

The total health care costs of asthma are likely substantial because it is so common. Surprisingly, there has been no systematic assessment of health care costs associated with asthma care in Canada since the early 1990s. The objective of the present study...

The total health care costs of asthma are likely substantial because it is so common. Surprisingly, there has been no systematic...

                        Trends in asthma-related direct medical costs from 2002 to 2007 in British Columbia, Canada: a population based-cohort study.
                      

The purpose of this population-based cohort study was to use BC administrative data to: 1) calculate the direct medical costs attributable to asthma in BC for the years 2002–2007; 2) evaluate asthma-related costs according to the level of asthma control; a...

The purpose of this population-based cohort study was to use BC administrative data to: 1) calculate the direct medical costs at...

Improving precision in the prediction of asthma exacerbations.

....

                        The association between previous and future severe exacerbations of chronic obstructive pulmonary disease: Updating the literature using robust statistical methodology.
                      

Using robust statistical methodology that controlled for heterogeneity in exacerbation rates among individuals, we demonstrated potential causal associations among past and future severe exacerbations, albeit the magnitude of association was noticeably low...

Using robust statistical methodology that controlled for heterogeneity in exacerbation rates among individuals, we demonstrated...

                        The “Lost NNT” can be used to represent uncertainty surrounding number needed to treat
                      

Currently, confidence interval is the standard way of communicating uncertainty around the number needed to treat (NNT). But the CI is not directly relevant to the treatment decision.Uncertainty around treatment only matters because it may result in the ch...

Currently, confidence interval is the standard way of communicating uncertainty around the number needed to treat (NNT). But the...

Faculty of Pharmaceutical Sciences & UBC Division of Respiratory Medicine Respiratory Evaluation Sciences Program

Faculty of Pharmaceutical Sciences & UBC Division of Respiratory Medicine
Respiratory Evaluation Sciences Program