THE UNIVERSITY OF BRITISH COLUMBIA
Project status
PUBLICATIONS:
The demonstrable value of precision medicine, in the context of common environmental exposures, has scarcely been explored. This study evaluated the cost effectiveness of a preventive personalised intervention to reduce the adverse effect of air pollution...
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Medical Decision Making. October 2021. doi:10.1177/0272989X211050909
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Respir Res. 2021 Apr 9;22(1):103. doi: 10.1186/s12931-021-01696-x
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Eur Respir J. 2021 Sep 9:2101186. doi: 10.1183/13993003.01186-2021
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Allergy Asthma Clin Immunol. 2021 Oct 12;17(1):108. doi: 10.1186/s13223-021-00610-w. PMID: 34641954.
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Med Decis Making. 2019 Feb;39(2):152-16
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JAMA. 2020 Jul 21;324(3):235-236
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We agree with Drs Goldstein and Pencina about the necessity of adapting risk models to the clinical use case. We share their vision that a cloud-based platform does not have to be centralized; each practitioner will set up their own environment for the mod...
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The International Severe Asthma Registry (ISAR) is a collaborative initiative comprising existing and new registries that builds on data from multiple nations and regions and increases the statistical power and comparability of data. It is the first global...
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The aim of this study is to develop a platform that allows: 1) policymakers to identify subgroups of the COPD population that are at increased risk of emergency department visits, hospitalization and mortality and 2) health economists to obtain input or va...
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There is sparse evidence that COPD exacerbations are associated with subsequent accelerated lung function decline, particularly in those with mild disease. Lung function decline is most accelerated at the early stages of COPD, and early identification of p...
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Eur Respir J. 2020 Aug 27;2002122. doi: 10.1183/13993003.02122-2020.
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Ann Am Thorac Soc. 2020 May 8.
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Respir Res. 2020 May 19;21(1):118
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Respiratory Medicine, 2020 (171); 106079
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The purpose of this clinical practice guideline is to address specific clinically important questions regarding the pharmacologic management of COPD. The expert panel, in collaboration with a team of methodologists, prioritized and developed six questions...
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This Lancet Respiratory Medicine describes a new prediction model to predict COPD exacerbations using simple clinical predictors
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Statistic in Medicine. 2020;10.1002/sim.8481
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A comment on the study "Preserved ratio impaired spirometry (PRISm) is a prevalent, neglected condition whose prognosis is close to that of COPD" by Wijnant et al. Given that PRISm resembles COPD in term of reduction in FEV1, but not in terms of FEV1/FVC r...
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J Allergy Clin Immunol. 2019;S0091-6749(19)31634-3
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Am J Epidemiol. 2016;184(9):681–689
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CMAJ. 2016;188(14):1004–1011
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J Gen Intern Med. 2018 Sep;33(9):1528-1535
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J Allergy Clin Immunol Pract. 2017 Nov - Dec;5(6):1663-1670.e5
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BMJ Open. 2013 Sep 4;3(9):e003360
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Ann Am Thorac Soc. 2016 Feb;13(2):188-96
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Chest. 2014 Apr;145(4):787-793
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Respir Res. 2016 Aug 26;17(1):106
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Arch Osteoporos. 2018 Oct 29;13(1):116
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J Asthma. 2019 Dec;56(12):1334-1346
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Clin Epidemiol. 2018 Jul 12;10:831-840
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Respir Res. 2018 Feb 7;19(1):26
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Respir Res. 2018 Feb 7;19(1):26
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Cost Eff Resour Alloc. 2018 Jan 30;16:3
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Int J Tuberc Lung Dis. 2014 Mar;18(3):254
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Respir Med. 2018 May;138:7-12
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Ann Epidemiol. 2018 Oct;28(10):717-723.e3
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Pharmacoeconomics. 2014 Oct;32(10):995-1004
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Chest. 2015 Apr;147(4):868-869
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Int J Tuberc Lung Dis. 2016 Jan;20(1):11-23
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PLoS One. 2012;7(10):e46746
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Chest. 2017 Mar;151(3):612-618
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BMC Pulm Med. 2018 Feb 12;18(1):33.
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Thorax. 2014 Apr;69(4):328-34
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J Allergy Clin Immunol. 2013 Jul;132(1):63-9
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J Clin Epidemiol. 2010 Mar;63(3):257-69
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Lancet Respir Med. 2015 Aug;3(8):631-9
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Med Care. 2016 Aug;54(8):789-95
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Eur Respir J. 2016 Dec;48(6):1584-1592
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Allergy. 2017 Feb;72(2):291-299
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J Allergy Clin Immunol. 2014 Oct;134(4):908-915.e3
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Am J Respir Crit Care Med. 2017 Feb 1;195(3):287-291
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Thorax. 2016 Mar;71(3):267-75
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PLoS One. 2016 Jan 11;11(1):e0146003
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Trials. 2014 Jun 3;15:201
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Cost Eff Resour Alloc. 2014 Mar 13;12(1):8
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Health Econ. 2013 Jul;22(7):877-82
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Value Health. 2013 Jan-Feb;16(1):66-75
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Eur Respir J. 2017 Jul 27;50(1). pii: 1700393
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Respir Med. 2017 Oct;131:135-140
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Thorax. 2014 Nov;69(11):1043-4
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Respir Med. 2015 Mar;109(3):320-8
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Allergy Asthma Clin Immunol. 2013 Dec 23;9(1):49
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Chest. 2013 Aug;144(2):428-435
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Lancet Respir Med. 2016 Jun;4(6):421-2
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Value Health. 2017;20(1):152–162
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Value Health. 2013;16(2):438–448
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Am J Respir Crit Care Med. 2019 Nov 1;200(9):1102-111
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Chest. 2019 Sep 19. pii: S0012-3692(19)33868-1
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Thorax. 2019 Dec;74(12):1113-1119
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Int J Chron Obstruct Pulmon Dis. 2019 Sep 3;14:2003-2013
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The objectives of this study were to evaluate the associations between 1) asthma control and work-related asthma (WRA), 2) productivity loss and WRA/NWRA status and 3) productivity loss and WRA/non-work-related asthma (NWRA) status in individuals with the...
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This study aimed at informing an evidence gap in the literature. We have used a prospectively recruited sample, longitudinal evaluation of costs and control, and updated definitions of asthma control (according to the Global Initiative for Asthma [GINA] 20...
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Previous studies have evaluated communication technologies in asthma care , but none of these studies have involved pharmacists.On the other hand, pharmacist-based studies on improving the management of asthma have hitherto used interventions whose real-wo...
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Using a longitudinal random sample of adults with asthma, we explored the performance of both generic and asthma-specific HRQoL instruments to simultaneously distinguish between different levels of asthma control and changes in comorbidity status. Our prim...
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The primary objective of this study was to quantify the gain in quality of life that can be achieved by achieving Global Initiative for Asthma (GINA) symptom control in patients with symptomatically uncontrolled or partially controlled asthma. We pursued s...
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The emphasis of asthma management is focussed on achieving current symptom control and the prevention of future risk. From this perspective, it is much more relevant to evaluate the interaction of asthma control and psychological distress (PD) in determini...
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Using a longitudinal random sample of adults with asthma, we explored the performance of both generic and asthma-specific HRQoL instruments to simultaneously distinguish between different levels of asthma control and changes in comorbidity status. Our prim...
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Commentary on Virchow et al. (Lancet. 2019, https://doi.org/10.1016/S0140-6736(19)32215-9)
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Lowering the #pvalue threshold for phase 3 RCTs is inappropriate, as high prior probability of replication (68%) leads to high positive predictive values (97%) when p=0.05
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Using administrative health data from a large province in Canada, we aimed to examine the long-term trajectory of mild asthma in adults older than 16 years and to identify demographic, clinical, and treatment-related factors during the earlier stages of di...
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Using administrative health data from a large province of Canada, we aimed to examine the long-term trajectory of mild asthma in adults over 16 years and to identify demographic,clinical, and treatment-related factors during the earlier stages of disease t...
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Identifying factors associated with inappropriate or excessive use of short-acting beta agonists (SABA) in asthma can help efforts towards safer use of such medications. We used British Columbian (BC)’s administrative health data to create a retrospective...
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Our primary objective in this study was to estimate the excess direct costs related to the care of patients with physician-diagnosed COPD from 2001 to 2010 in British Columbia. The secondary objectives were to evaluate the relative contributions of the var...
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The total health care costs of asthma are likely substantial because it is so common. Surprisingly, there has been no systematic assessment of health care costs associated with asthma care in Canada since the early 1990s. The objective of the present study...
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The purpose of this population-based cohort study was to use BC administrative data to: 1) calculate the direct medical costs attributable to asthma in BC for the years 2002–2007; 2) evaluate asthma-related costs according to the level of asthma control; a...
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Using robust statistical methodology that controlled for heterogeneity in exacerbation rates among individuals, we demonstrated potential causal associations among past and future severe exacerbations, albeit the magnitude of association was noticeably low...
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Currently, confidence interval is the standard way of communicating uncertainty around the number needed to treat (NNT). But the CI is not directly relevant to the treatment decision.Uncertainty around treatment only matters because it may result in the ch...
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SOFTWARE:
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PUBLICATIONS:
Does the occurrence of a severe asthma exacerbation affect the rate of subsequent events? To the best of our knowledge, this important question has not been evaluated in asthma. Conventional wisdom is that previous history of asthma exacerbations is the be...
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Primary care-based programs for improving the early detection of COPD are very likely to be cost-effective with high adherence to guideline-recommended treatment following diagnosis.
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Under review
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In pooled data of 10,759 COPD patients from 7 clinical trials (median follow up of 5 years), we examined the non-linear relationships of BMI with the rate of decline in Forced Expiratory Volume in One Second (FEV1) using restricted cubic spline regressions...
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Understanding the current status of medication use in mild asthma will help illuminate the potential benefit of the permeation of new recommendations on the earlier use of controller therapies. Accordingly, the purpose of the present study was to document...
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Using data from a population-based prospective cohort, we assessed the burden of self reported respiratory symptoms in patients with persistent airflow limitation in order to (1) characterize variation in the occurrence of symptoms between individuals, and...
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Population-based databases are uniquely positioned to provide robust estimates of the extent and trends of OCS use. Such databases are not affected by the self-selection of individuals into private insurance plans, or the strict inclusion criteria of patie...
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We used a longitudinal population-based cohort of individuals with physician-diagnosed asthma to compare total direct asthma-related healthcare costs in patients with a confirmed diagnosis of asthma versus patients in whom a diagnosis of asthma was ruled o...
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