THE UNIVERSITY OF BRITISH COLUMBIA

Faculty of Pharmaceutical Sciences & UBC Division of Respiratory Medicine
Respiratory Evaluation Sciences Program

Research Specific Projects

IMPLEMENTING PREDICTIVE ANALYTICS TOWARDS EFFICIENT COPD TREATMENTS (IMPACT)

ABOUT:

With a phased implementation of a harmonized electronic health records (EHR) system across all tertiary care centres, British Columbia (BC) is in the midst of a transformational change in health care delivery. Our 23-member research team comprised of patients, care providers, knowledge users, administrators, researchers, and implementation sciences and knowledge translation experts, is ideally positioned to lead this unique IMPACT (IMplementing Predictive Analytics towards efficient COPD Treatments) study. Our objective is to implement and evaluate Precision Medicine tools for the care of patients with Chronic Obstructive Pulmonary Disease (COPD). Our proposed intervention is a Clinical Prediction Model (CPM), integrated within EHR and powered by advanced Natural Language Processing to provide a user-friendly human-computer interface. It can assess the risk of COPD exacerbations, communicate risk, and recommend personalized pharmacotherapies and lifestyle modifications via shared decision making. As part of our integrated knowledge translation (iKT) approach, we will engage patients and care providers as research partners to co-design and integrate this tool into clinical workflow. We will implement the finalized tool in two of the largest teaching hospitals in BC, and will conduct a pragmatic stepped-wedge cluster randomized controlled trial (RCT) to evaluate its impact on: prescription patterns, medication adherence, patient-reported outcomes, exacerbation rates, and sex- and gender-disparities in COPD care. The multidimensional data from this study will inform a previously validated Canadian health economics model of COPD, allowing us to assess the cost-effectiveness of large-scale implementation of such an intervention. This project will create a lasting collaboration among an interdisciplinary team to support a continuous program of promoting predictive analytics in clinical decision-making. Through this, IMPACT will not only improve COPD care and outcomes, but can also serve as a template for other chronic diseases.

Team:

Principal Investigators:

Management team:

  • Paloma Burns (project management)
  • Alexander Lin (project management)

Co-investigators:

Collaborators:

Knowledge users:

PARTNERS:

PUBLICATIONS:

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MORE RESEARCH

Specific Project
NOVEL OBSERVATIONAL LONGITUDINAL STUDY (NOVELTY)

NOVELTY is a prospective cohort study conducted from 2016-2021, with data from 11,243 patients across 18 countries. Individuals with a diagnosis, or suspected diagnosis, of asthma and/or COPD (including 1652 patients with severe asthma) were included in the study. NOVELTY contains a rich set of socio-demographic, clinical, and anthropometric patient data, including spirometry measurements, medication utilization, basic sociodemographic information, and health services use.

See 1 publication

Specific Project
EVALUATION PLATFORM IN COPD (EPIC)

EPIC is a comprehensive epidemiologic and decision-analytic model for chronic obstructive pulmonary disease (COPD) in Canada.

See 8 publications

Specific Project
ACUTE COPD EXACERBATION PREDICTION TOOL (ACCEPT)

The Acute COPD Exacerbation Prediction Tool (ACCEPT) is a validated clinical prediction model that predicts rate and severity of COPD exacerbations.

See 4 publications

Specific Project
PRISM: PROGRAMMABLE INTERFACE FOR STATISTICAL & SIMULATION MODELS

PRISM is a platform that makes decision-analytics and clinical prediction models accessible on the cloud. PRISM enables end-users to intract with the model they are interested in, without worrying about having the required hardware resources, or setting up complex code on their computer.

See 3 publications

Specific Project
EHEALTH TOOLS FOR PRECISION MEDICINE IN COPD

This CIHR-funded project aims at devloping and validating prediction tools for precision disease management for COPD, and implementing such tools as Web Apps to be freely accessible to the patient and care provider community.

See 6 publications

Specific Project
NATURAL HISTORY AND PATTERNS OF MEDICATION USE IN ASTHMA

This project, sponsored by an arm's length reserch contract with AstraZeneca Canada, harnesses population-based administrative health databases of British Columbia to update our esitmates of the recent trends in medication use in asthma. The emphasis of this project is on the use of short-acting beta agonists and systemic corticosteroids and how their pattern of use is evolving in patients with asthma.

See 7 publications

Specific Project
PRECISION HEALTH IN CHILDHOOD AND ADULT ASTHMA

This is an exciting multidiciplinary project on Precision Health in children and adult asthma. This project has spon off from our lab's involvement in a major Genome Canada grant (PI: [Dr. Stuart Turvey](https://bcchr.ca/our-research/researchers/results/Details/stuart-turvey)). We plan to develop Whole Disease Policy models for childhood and adult lung health and provide rigorous decision-theoretic lens to biomarker discovery activities that target lung health in children and adults.

See 3 publications

Specific Project
ECONOMIC BURDEN OF ASTHMA (EBA)

EBA was a one-year, prospective study of a population-based random sample of 622 patients with asthma in British Columbia, with the main objective of estimating the burden of asthma in terms of its direct costs, indirect costs, and quality of life.

See 12 publications

SEE ALSO

THEME

Describes the main theme used (Asthma, COPD, methodological research).

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METHODOLOGY

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