RESP

International variation in severe exacerbation rates in patients with severe asthma

Lee TY, Price D, Yadav CP, Roy R, Mien LLH, Wang E, Wechsler ME, Jackson DJ, Busby J, Heaney LG, Pfeffer PE, Mahboub B, Perng Steve DW, Cosio BG, Perez-de-Llano L, Al-Lehebi R, Larenas-Linnemann D, Al-Ahmad M, Rhee CK, Iwanaga T, Heffler E, Canonica GW, Co...

Lee TY, Price D, Yadav CP, Roy R, Mien LLH, Wang E, Wechsler ME, Jackson DJ, Busby J, Heaney LG, Pfeffer PE, Mahboub B, Perng St...

High-Efficiency Particulate Air Filters for Preventing Wildfire-related Asthma Complications: A Cost-Effectiveness Study

Adibi A, Barn P, Shellington EM, Harvard S, Johnson KM, Carlsten C. High-Efficiency Particulate Air Filters for Preventing Wildfire-related Asthma Complications: A Cost-Effectiveness Study. Am J Respir Crit Care Med. 2024 Jan 15;209(2):175-184. doi: 10.116...

Adibi A, Barn P, Shellington EM, Harvard S, Johnson KM, Carlsten C. High-Efficiency Particulate Air Filters for Preventing Wildf...

Cost-effectiveness of budesonide-formoterol vs inhaled epinephrine in US adults with mild asthma

Ho JK, Shaker M, Greenhawt M, Sadatsafavi M, Abrams EM, Oppenheimer J, Mosnaim GS, Lee TY, Johnson KM. Cost-effectiveness of budesonide-formoterol vs inhaled epinephrine in US adults with mild asthma. Ann Allergy Asthma Immunol. 2023 Oct 23:S1081-1206(23)0...

Ho JK, Shaker M, Greenhawt M, Sadatsafavi M, Abrams EM, Oppenheimer J, Mosnaim GS, Lee TY, Johnson KM. Cost-effectiveness of bud...

Development of a conceptual model of childhood asthma to inform asthma prevention policies

Adibi A, Turvey SE, Lee TY, Sears MR, Becker AB, Mandhane PJ, Moraes TJ, Subbarao P, Sadatsafavi M. Development of a conceptual model of childhood asthma to inform asthma prevention policies. BMJ Open Respir Res. 2021 Nov;8(1):e000881. doi: 10.1136/bmjresp...

Adibi A, Turvey SE, Lee TY, Sears MR, Becker AB, Mandhane PJ, Moraes TJ, Subbarao P, Sadatsafavi M. Development of a conceptual...

Long-term natural history of severe asthma exacerbations and their impact on the disease course

Lee TY, Petkau J, Sadatsafavi M. Long-Term Natural History of Severe Asthma Exacerbations and Their Impact on the Disease Course. Ann Am Thorac Soc. 2022 Jun;19(6):907-915. doi: 10.1513/AnnalsATS.202012-1562OC.

Lee TY, Petkau J, Sadatsafavi M. Long-Term Natural History of Severe Asthma Exacerbations and Their Impact on the Disease Course...

Association between asthma control trajectories in preschoolers and long-term asthma control

Longo C, Blais L, Brownell M, Quail JM, Sadatsafavi M, Forget A, Turcot MA, Li W, Sidhu N, Tavakoli H, Tan Q, Platt RW, Ducharme FM. Association Between Asthma Control Trajectories in Preschoolers and Long-Term Asthma Control. J Allergy Clin Immunol Pract....

Longo C, Blais L, Brownell M, Quail JM, Sadatsafavi M, Forget A, Turcot MA, Li W, Sidhu N, Tavakoli H, Tan Q, Platt RW, Ducharme...

16-year trends in asthma hospital admissions in Canada

Lee TY, Petkau J, Mangat N, Safari A, Cragg JJ, Lynd LD, FitzGerald JM, Turvey SE, Sadatsafavi M. 16-year trends in asthma hospital admissions in Canada. Ann Allergy Asthma Immunol. 2022 Oct;129(4):475-480.e2. doi: 10.1016/j.anai.2022.06.022.

Lee TY, Petkau J, Mangat N, Safari A, Cragg JJ, Lynd LD, FitzGerald JM, Turvey SE, Sadatsafavi M. 16-year trends in asthma hospi...

The burden of mild asthma: Clinical burden and healthcare resource utilisation in the NOVELTY study

Golam SM, Janson C, Beasley R, FitzGerald JM, Harrison T, Chipps B, Hughes R, Müllerová H, Olaguibel JM, Rapsomaniki E, Reddel HK, Sadatsafavi M; NOVELTY study investigators. The burden of mild asthma: Clinical burden and healthcare resource utilisation in...

Golam SM, Janson C, Beasley R, FitzGerald JM, Harrison T, Chipps B, Hughes R, Müllerová H, Olaguibel JM, Rapsomaniki E, Reddel H...

Trends in oral corticosteroids use in severe asthma: a 14-year population-based study

Respir Res. 2021 Apr 9;22(1):103. doi: 10.1186/s12931-021-01696-x

The cost-effectiveness of as-needed budesonide-formoterol versus low-dose inhaled corticosteroid maintenance therapy in patients with mild asthma in Canada

Allergy Asthma Clin Immunol. 2021 Oct 12;17(1):108. doi: 10.1186/s13223-021-00610-w. PMID: 34641954.

International severe asthma registry (ISAR): protocol for a global registry

The International Severe Asthma Registry (ISAR) is a collaborative initiative comprising existing and new registries that builds on data from multiple nations and regions and increases the statistical power and comparability of data. It is the first global...

The International Severe Asthma Registry (ISAR) is a collaborative initiative comprising existing and new registries that builds...

Does the occurrence of a severe asthma exacerbation change the rate of subsequent events?

Does the occurrence of a severe asthma exacerbation affect the rate of subsequent events? To the best of our knowledge, this important question has not been evaluated in asthma. Conventional wisdom is that previous history of asthma exacerbations is the be...

Does the occurrence of a severe asthma exacerbation affect the rate of subsequent events? To the best of our knowledge, this imp...

The cost-effectiveness of as-needed budesonide/formoterol versus low-dose inhaled corticosteroid maintenance therapy in patients with mild asthma in the UK

Respiratory Medicine, 2020 (171); 106079

Cost-effectiveness of Implementing Objective Diagnostic Verification of Asthma in the United States

J Allergy Clin Immunol. 2019;S0091-6749(19)31634-3

Stability of asthma symptom control in a longitudinal study of mild–moderate asthmatics

J Allergy Clin Immunol Pract. 2017 Nov - Dec;5(6):1663-1670.e5

Complementary and alternative asthma treatments and their association with asthma control: a population-based study

BMJ Open. 2013 Sep 4;3(9):e003360

History of Asthma in Patients with Chronic Obstructive Pulmonary Disease: A Comparative Study of Economic Burden.

Ann Am Thorac Soc. 2016 Feb;13(2):188-96

The preventable burden of productivity loss due to suboptimal asthma control: a population-based study

Chest. 2014 Apr;145(4):787-793

The impact of comorbidities on productivity loss in asthma patients

Respir Res. 2016 Aug 26;17(1):106

Long-term effects of inhaled corticosteroids on bone mineral density in older women with asthma or COPD: a registry-based cohort study

Arch Osteoporos. 2018 Oct 29;13(1):116

A systematic review of the adverse events and economic impact associated with oral corticosteroids in asthma

J Asthma. 2019 Dec;56(12):1334-1346

Asthma is not associated with the need for surgery in Crohn’s disease when controlling for smoking status: a population-based cohort study.

Clin Epidemiol. 2018 Jul 12;10:831-840

Cost-effectiveness of tiotropium versus omalizumab for uncontrolled allergic asthma in US

Cost Eff Resour Alloc. 2018 Jan 30;16:3

The importance of measuring asthma control in emerging economies.

Int J Tuberc Lung Dis. 2014 Mar;18(3):254

The projected economic and health burden of sub-optimal asthma control in Canada

Respir Med. 2018 May;138:7-12

Has asthma medication use caught up with the evidence? A 12-year population-based study of trends

Chest. 2017 Mar;151(3):612-618

Predictors of inappropriate usage of reliever medications in asthma: a 12-year population-based study

BMC Pulm Med. 2018 Feb 12;18(1):33.

Dispensation of long-acting β agonists with or without inhaled corticosteroids, and risk of asthma-related hospitalisation: a population-based study

Thorax. 2014 Apr;69(4):328-34

Comparative outcomes of leukotriene receptor antagonists and long-acting β-agonists as add-on therapy in asthmatic patients: a population-based study

J Allergy Clin Immunol. 2013 Jul;132(1):63-9

Influences of Socioeconomic Status on Costs of Asthma Under Universal Health Coverage

Med Care. 2016 Aug;54(8):789-95

Excess medical costs in patients with asthma and the role of comorbidity

Eur Respir J. 2016 Dec;48(6):1584-1592

Ten-year trends in direct costs of asthma: a population-based study

Allergy. 2017 Feb;72(2):291-299

Economic and health effect of full adherence to controller therapy in adults with uncontrolled asthma: A simulation study

J Allergy Clin Immunol. 2014 Oct;134(4):908-915.e3

The natural history of severe asthma and influences of early risk factors: a population-based cohort study

Thorax. 2016 Mar;71(3):267-75

Cost-effectiveness of bronchial thermoplasty, omalizumab, and standard therapy for moderate-to-severe allergic asthma

PLoS One. 2016 Jan 11;11(1):e0146003

The impact of inappropriate use of short acting beta agonists in asthma

Respir Med. 2017 Oct;131:135-140

One-year outcomes of inhaled controller therapies added to systemic corticosteroids after asthma-related hospital discharge

Respir Med. 2015 Mar;109(3):320-8

Post-hospital syndrome in adults with asthma: a case-crossover study

Allergy Asthma Clin Immunol. 2013 Dec 23;9(1):49

Costs and health outcomes associated with primary versus secondary care after an asthma-related hospitalization, a population-based study

Chest. 2013 Aug;144(2):428-435

Less chaos in the prognosis of asthma-chronic obstructive lung disease overlap.

Lancet Respir Med. 2016 Jun;4(6):421-2

The projected economic and health burden of uncontrolled asthma in the United States

Am J Respir Crit Care Med. 2019 Nov 1;200(9):1102-111

The economic burden of multimorbidity in severe asthma patients: a 20-year population-based study

Thorax. 2019 Dec;74(12):1113-1119

Asthma control and productivity loss in those with work-related asthma: a population-based study

The objectives of this study were to evaluate the associations between 1) asthma control and work-related asthma (WRA), 2) productivity loss and WRA/NWRA status and 3) productivity loss and WRA/non-work-related asthma (NWRA) status in individuals with the...

The objectives of this study were to evaluate the associations between 1) asthma control and work-related asthma (WRA), 2) produ...

Saving in medical costs by achieving guideline-based asthma symptom control: a population-based study

This study aimed at informing an evidence gap in the literature. We have used a prospectively recruited sample, longitudinal evaluation of costs and control, and updated definitions of asthma control (according to the Global Initiative for Asthma [GINA] 20...

This study aimed at informing an evidence gap in the literature. We have used a prospectively recruited sample, longitudinal eva...

Empowering pharmacists in asthma management through interactive SMS (EmPhAsIS): study protocol for a randomized controlled trial.

Previous studies have evaluated communication technologies in asthma care , but none of these studies have involved pharmacists.On the other hand, pharmacist-based studies on improving the management of asthma have hitherto used interventions whose real-wo...

Previous studies have evaluated communication technologies in asthma care , but none of these studies have involved pharmacists....

The additional burden of comorbidity along with asthma control on health-related quality of life in asthma

Using a longitudinal random sample of adults with asthma, we explored the performance of both generic and asthma-specific HRQoL instruments to simultaneously distinguish between different levels of asthma control and changes in comorbidity status. Our prim...

Using a longitudinal random sample of adults with asthma, we explored the performance of both generic and asthma-specific HRQoL...

Quality of life and asthma symptom control: room for improvement in care and measurement

The primary objective of this study was to quantify the gain in quality of life that can be achieved by achieving Global Initiative for Asthma (GINA) symptom control in patients with symptomatically uncontrolled or partially controlled asthma. We pursued s...

The primary objective of this study was to quantify the gain in quality of life that can be achieved by achieving Global Initiat...

Interaction effect of psychological distress and asthma control on productivity loss in patients with asthma: a population-based study

The emphasis of asthma management is focussed on achieving current symptom control and the prevention of future risk. From this perspective, it is much more relevant to evaluate the interaction of asthma control and psychological distress (PD) in determini...

The emphasis of asthma management is focussed on achieving current symptom control and the prevention of future risk. From this...

The added effect of comorbidity on health-related quality of life in patients with asthma.

Using a longitudinal random sample of adults with asthma, we explored the performance of both generic and asthma-specific HRQoL instruments to simultaneously distinguish between different levels of asthma control and changes in comorbidity status. Our prim...

Using a longitudinal random sample of adults with asthma, we explored the performance of both generic and asthma-specific HRQoL...

Triple therapy in a single inhaler: a new option for uncontrolled asthma

Commentary on Virchow et al. (Lancet. 2019, https://doi.org/10.1016/S0140-6736(19)32215-9)

Long-Term Trajectories of Mild Asthma in Adulthood and Risk Factors of Progression

Using administrative health data from a large province in Canada, we aimed to examine the long-term trajectory of mild asthma in adults older than 16 years and to identify demographic, clinical, and treatment-related factors during the earlier stages of di...

Using administrative health data from a large province in Canada, we aimed to examine the long-term trajectory of mild asthma in...

Extent, trends, and determinants of controller/reliever balance in mild asthma: a 14-year population-based study

Understanding the current status of medication use in mild asthma will help illuminate the potential benefit of the permeation of new recommendations on the earlier use of controller therapies. Accordingly, the purpose of the present study was to document...

Understanding the current status of medication use in mild asthma will help illuminate the potential benefit of the permeation o...

Trends in systemic corticosteroids use in severe asthma: a 14-year population-based study

Population-based databases are uniquely positioned to provide robust estimates of the extent and trends of OCS use. Such databases are not affected by the self-selection of individuals into private insurance plans, or the strict inclusion criteria of patie...

Population-based databases are uniquely positioned to provide robust estimates of the extent and trends of OCS use. Such databas...

The costs of misdiagnosed asthma in a longitudinal study of the general population

We used a longitudinal population-based cohort of individuals with physician-diagnosed asthma to compare total direct asthma-related healthcare costs in patients with a confirmed diagnosis of asthma versus patients in whom a diagnosis of asthma was ruled o...

We used a longitudinal population-based cohort of individuals with physician-diagnosed asthma to compare total direct asthma-rel...

Direct health care costs associated with asthma in British Columbia.

The total health care costs of asthma are likely substantial because it is so common. Surprisingly, there has been no systematic assessment of health care costs associated with asthma care in Canada since the early 1990s. The objective of the present study...

The total health care costs of asthma are likely substantial because it is so common. Surprisingly, there has been no systematic...

Trends in asthma-related direct medical costs from 2002 to 2007 in British Columbia, Canada: a population based-cohort study.

The purpose of this population-based cohort study was to use BC administrative data to: 1) calculate the direct medical costs attributable to asthma in BC for the years 2002–2007; 2) evaluate asthma-related costs according to the level of asthma control; a...

The purpose of this population-based cohort study was to use BC administrative data to: 1) calculate the direct medical costs at...

Improving precision in the prediction of asthma exacerbations.

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Can we predict who will benefit most from biologics in severe asthma? A post-hoc analysis of two phase 3 trials

Can we predict who will benefit most from biologics in severe asthma? A post-hoc analysis of two phase 3 trials. Respir Res. 2023 May 2;24(1):120. doi: 10.1186/s12931-023-02409-2.

Can we predict who will benefit most from biologics in severe asthma? A post-hoc analysis of two phase 3 trials. Respir Res. 202...

Individualised risk prediction model for exacerbations in patients with severe asthma: protocol for a multicentre real-world risk modelling study

Individualised risk prediction model for exacerbations in patients with severe asthma: protocol for a multicentre real-world risk modelling study. BMJ Open. 2023 Mar 9;13(3):e070459. doi: 10.1136/bmjopen-2022-070459

Individualised risk prediction model for exacerbations in patients with severe asthma: protocol for a multicentre real-world ris...

Faculty of Pharmaceutical Sciences & UBC Division of Respiratory Medicine Respiratory Evaluation Sciences Program

Faculty of Pharmaceutical Sciences & UBC Division of Respiratory Medicine
Respiratory Evaluation Sciences Program