RESP

QRISK3 underestimates the risk of cardiovascular events in patients with COPD

Amegadzie JE, Gao Z, Quint JK, Russell R, Hurst JR, Lee TY, Sin DD, Chen W, Bafadhel M, Sadatsafavi M. QRISK3 underestimates the risk of cardiovascular events in patients with COPD. Thorax. 2023 Nov 27:thorax-2023-220615. doi: 10.1136/thorax-2023-220615. E...

Amegadzie JE, Gao Z, Quint JK, Russell R, Hurst JR, Lee TY, Sin DD, Chen W, Bafadhel M, Sadatsafavi M. QRISK3 underestimates the...

A Cost-Effectiveness Analysis of Azithromycin for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Ahmadian S, Johnson KM, Ho JK, Sin DD, Lynd LD, Harrison M, Sadatsafavi M. A Cost-Effectiveness Analysis of Azithromycin for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2023 Dec;20(12):1735-1742. doi:...

Ahmadian S, Johnson KM, Ho JK, Sin DD, Lynd LD, Harrison M, Sadatsafavi M. A Cost-Effectiveness Analysis of Azithromycin for the...

Risk and distribution of chronic obstructive pulmonary disease-related hospitalizations among primary care patients

Can Fam Physician. 2023 Jun;69(6):409-414. doi: 10.46747/cfp.6906409. PMID: 37315968; PMCID: PMC10266388.

The hidden and unchecked judgement calls when using exacerbation history for managing COPD

Sadatsafavi M, Aaron SD, Gershon AS, Puhan M, Adibi A, Sin DD. The Hidden and Unchecked Judgement Calls When Using Exacerbation History for Managing COPD. Arch Bronconeumol. 2022 Sep;58(9):629-631. English, Spanish. doi: 10.1016/j.arbres.2021.09.018.

Sadatsafavi M, Aaron SD, Gershon AS, Puhan M, Adibi A, Sin DD. The Hidden and Unchecked Judgement Calls When Using Exacerbation...

Benefit-harm analysis of azithromycin for the prevention of acute exacerbations of chronic obstructive pulmonary disease

Ahmadian S, Sin DD, Lynd L, Harrison M, Sadatsafavi M. Benefit-harm analysis of azithromycin for the prevention of acute exacerbations of chronic obstructive pulmonary disease. Thorax. 2022 Nov;77(11):1079-1087. doi: 10.1136/thoraxjnl-2021-217962.

Ahmadian S, Sin DD, Lynd L, Harrison M, Sadatsafavi M. Benefit-harm analysis of azithromycin for the prevention of acute exacerb...

A personalized biomedical risk assessment infographic for people who smoke with COPD: a qualitative study

Gupta S, Panchal P, Sadatsafavi M, Ghanouni P, Sin D, Pakhale S, To T, Zafari Z, Nimmon L; Canadian Respiratory Research Network. A personalized biomedical risk assessment infographic for people who smoke with COPD: a qualitative study. Addict Sci Clin Pra...

Gupta S, Panchal P, Sadatsafavi M, Ghanouni P, Sin D, Pakhale S, To T, Zafari Z, Nimmon L; Canadian Respiratory Research Network...

External validation of lung function predictions in real-world cohorts of COPD

Zafari Z, Lee TY, Sadatsafavi M. External validation of lung function predictions in real-world cohorts of COPD. Respir Med. 2022 Jul;198:106859. doi: 10.1016/j.rmed.2022.106859.

Zafari Z, Lee TY, Sadatsafavi M. External validation of lung function predictions in real-world cohorts of COPD. Respir Med. 202...

ACCEPT 2·0: Recalibrating and externally validating the Acute COPD exacerbation prediction tool (ACCEPT)

Safari A, Adibi A, Sin DD, Lee TY, Ho JK, Sadatsafavi M. ACCEPT 2·0: Recalibrating and externally validating the Acute COPD exacerbation prediction tool (ACCEPT). EClinicalMedicine. 2022 Jul 22;51:101574. doi: 10.1016/j.eclinm.2022.101574.

Safari A, Adibi A, Sin DD, Lee TY, Ho JK, Sadatsafavi M. ACCEPT 2·0: Recalibrating and externally validating the Acute COPD exac...

Generalizability of risk stratification algorithms for exacerbations in COPD

Ho JK, Safari A, Adibi A, Sin DD, Johnson K, Sadatsafavi M; IMPACT study. Generalizability of risk stratification algorithms for exacerbations in COPD. Chest. 2022 Dec 9:S0012-3692(22)04216-7. doi: 10.1016/j.chest.2022.11.041.

Ho JK, Safari A, Adibi A, Sin DD, Johnson K, Sadatsafavi M; IMPACT study. Generalizability of risk stratification algorithms for...

Understanding resource utilization and mortality in COPD to support policy making: A microsimulation study

The aim of this study is to develop a platform that allows: 1) policymakers to identify subgroups of the COPD population that are at increased risk of emergency department visits, hospitalization and mortality and 2) health economists to obtain input or va...

The aim of this study is to develop a platform that allows: 1) policymakers to identify subgroups of the COPD population that ar...

The Long-Term Burden of COPD Exacerbations During Maintenance Therapy and Lung Function Decline

There is sparse evidence that COPD exacerbations are associated with subsequent accelerated lung function decline, particularly in those with mild disease. Lung function decline is most accelerated at the early stages of COPD, and early identification of p...

There is sparse evidence that COPD exacerbations are associated with subsequent accelerated lung function decline, particularly...

Should the number of acute exacerbations in the previous year be used to guide treatments in COPD?

Eur Respir J. 2020 Aug 27;2002122. doi: 10.1183/13993003.02122-2020.

Predicting Severe COPD Exacerbations: Developing a Population Surveillance Approach with Administrative Data

Ann Am Thorac Soc. 2020 May 8.

Statin use and lung cancer risk in chronic obstructive pulmonary disease patients: a population-based cohort study

Respir Res. 2020 May 19;21(1):118

Pharmacologic Management of Chronic Obstructive Pulmonary Disease. An Official American Thoracic Society Clinical Practice Guideline

The purpose of this clinical practice guideline is to address specific clinically important questions regarding the pharmacologic management of COPD. The expert panel, in collaboration with a team of methodologists, prioritized and developed six questions...

The purpose of this clinical practice guideline is to address specific clinically important questions regarding the pharmacologi...

Looking at the COPD spectrum through “PRISm”

A comment on the study "Preserved ratio impaired spirometry (PRISm) is a prevalent, neglected condition whose prognosis is close to that of COPD" by Wijnant et al. Given that PRISm resembles COPD in term of reduction in FEV1, but not in terms of FEV1/FVC r...

A comment on the study "Preserved ratio impaired spirometry (PRISm) is a prevalent, neglected condition whose prognosis is close...

Individualized prediction of lung-function decline in chronic obstructive pulmonary disease

CMAJ. 2016;188(14):1004–1011

The Impact of Care Specialty on Survival-Adjusted Medical Costs of COPD Patients After a Hospitalization: a longitudinal analysis.

J Gen Intern Med. 2018 Sep;33(9):1528-1535

The diagnostic performance of patient symptoms in screening for COPD

Respir Res. 2018 Feb 7;19(1):26

Characterizing undiagnosed chronic obstructive pulmonary disease: a systematic review and meta-analysis

Respir Res. 2018 Feb 7;19(1):26

COPD: undefeated!

Chest. 2015 Apr;147(4):868-869

The global economic burden of asthma and chronic obstructive pulmonary disease

Int J Tuberc Lung Dis. 2016 Jan;20(1):11-23

Future impact of various interventions on the burden of COPD in Canada: a dynamic population model.

PLoS One. 2012;7(10):e46746

Risk of cardiovascular comorbidity in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.

Lancet Respir Med. 2015 Aug;3(8):631-9

The Projected Epidemic Of COPD Hospitalizations Over the Next 15 Years: A Population Based Perspective

Am J Respir Crit Care Med. 2017 Feb 1;195(3):287-291

Excess economic burden of comorbidities in COPD: a 15-year population-based study

Eur Respir J. 2017 Jul 27;50(1). pii: 1700393

Heterogeneity’s ruses: the neglected role of between-individual variability in longitudinal studies of COPD exacerbations

Thorax. 2014 Nov;69(11):1043-4

A systematic review of health economics simulation models of chronic obstructive pulmonary disease

Value Health. 2017;20(1):152–162

Predicting severe COPD exacerbations: A population surveillance approach with administrative data

Under review

An individualized prediction model for long-term lung function trajectory and risk of COPD in the general population

Chest. 2019 Sep 19. pii: S0012-3692(19)33868-1

Trends in prescriptions and costs of inhaled medications in chronic obstructive pulmonary disease: a 19-year population-based study from Canada

Int J Chron Obstruct Pulmon Dis. 2019 Sep 3;14:2003-2013

The Relationship between Body Mass Index and Rate of Lung Function Decline among COPD Patients: a nonlinear regression analysis

In pooled data of 10,759 COPD patients from 7 clinical trials (median follow up of 5 years), we examined the non-linear relationships of BMI with the rate of decline in Forced Expiratory Volume in One Second (FEV1) using restricted cubic spline regressions...

In pooled data of 10,759 COPD patients from 7 clinical trials (median follow up of 5 years), we examined the non-linear relation...

Heterogeneity in the respiratory symptoms of patients with mild-moderate COPD

Using data from a population-based prospective cohort, we assessed the burden of self reported respiratory symptoms in patients with persistent airflow limitation in order to (1) characterize variation in the occurrence of symptoms between individuals, and...

Using data from a population-based prospective cohort, we assessed the burden of self reported respiratory symptoms in patients...

Ten-Year Trends in Direct Costs of COPD: A Population-Based Study.

Our primary objective in this study was to estimate the excess direct costs related to the care of patients with physician-diagnosed COPD from 2001 to 2010 in British Columbia. The secondary objectives were to evaluate the relative contributions of the var...

Our primary objective in this study was to estimate the excess direct costs related to the care of patients with physician-diagn...

The association between previous and future severe exacerbations of chronic obstructive pulmonary disease: Updating the literature using robust statistical methodology.

Using robust statistical methodology that controlled for heterogeneity in exacerbation rates among individuals, we demonstrated potential causal associations among past and future severe exacerbations, albeit the magnitude of association was noticeably low...

Using robust statistical methodology that controlled for heterogeneity in exacerbation rates among individuals, we demonstrated...

Generalizability of Risk Stratification Algorithms for Exacerbations in COPD

IMPACT Study. Generalizability of Risk Stratification Algorithms for Exacerbations in COPD. Chest. 2023 Apr;163(4):790-798. doi: 10.1016/j.chest.2022.11.041

IMPACT Study. Generalizability of Risk Stratification Algorithms for Exacerbations in COPD. Chest. 2023 Apr;163(4):790-798. doi:...

IMplementing Predictive Analytics towards efficient COPD Treatments (IMPACT): protocol for a stepped-wedge cluster randomized impact study

IMPACT Study Group. IMplementing Predictive Analytics towards efficient COPD Treatments (IMPACT): protocol for a stepped-wedge cluster randomized impact study. Diagn Progn Res. 2023 Feb 14;7(1):3. doi: 10.1186/s41512-023-00140-6

IMPACT Study Group. IMplementing Predictive Analytics towards efficient COPD Treatments (IMPACT): protocol for a stepped-wedge c...

IMplementing Predictive Analytics towards efficient COPD Treatments (IMPACT): protocol for a stepped-wedge cluster randomized impact study.

Michaux KD, Metcalfe RK, Burns P, Conklin AI, Hoens AM, Smith D, Struik L, Safari A, Sin DD, Sadatsafavi M; IMPACT Study Group. IMplementing Predictive Analytics towards efficient COPD Treatments (IMPACT): protocol for a stepped-wedge cluster randomized im...

Michaux KD, Metcalfe RK, Burns P, Conklin AI, Hoens AM, Smith D, Struik L, Safari A, Sin DD, Sadatsafavi M; IMPACT Study Group....

The burden of mild asthma: Clinical burden and healthcare resource utilisation in the NOVELTY study

Golam SM, Janson C, Beasley R, FitzGerald JM, Harrison T, Chipps B, Hughes R, Müllerová H, Olaguibel JM, Rapsomaniki E, Reddel HK, Sadatsafavi M; NOVELTY study investigators. The burden of mild asthma: Clinical burden and healthcare resource utilisation in...

Golam SM, Janson C, Beasley R, FitzGerald JM, Harrison T, Chipps B, Hughes R, Müllerová H, Olaguibel JM, Rapsomaniki E, Reddel H...

Moving beyond AUC: decision curve analysis for quantifying net benefit of risk prediction models

Eur Respir J. 2021 Sep 9:2101186. doi: 10.1183/13993003.01186-2021

The Acute COPD Exacerbation Prediction Tool (ACCEPT): a modelling study

This Lancet Respiratory Medicine describes a new prediction model to predict COPD exacerbations using simple clinical predictors

Cost-Effectiveness of Case Detection Strategies for the Early Detection of COPD

Primary care-based programs for improving the early detection of COPD are very likely to be cost-effective with high adherence to guideline-recommended treatment following diagnosis.

Primary care-based programs for improving the early detection of COPD are very likely to be cost-effective with high adherence t...

The association between rate and severity of exacerbations in chronic obstructive pulmonary disease: an application of a joint frailty-logistic model

Am J Epidemiol. 2016;184(9):681–689

History of Asthma in Patients with Chronic Obstructive Pulmonary Disease: A Comparative Study of Economic Burden.

Ann Am Thorac Soc. 2016 Feb;13(2):188-96

Long-term effects of inhaled corticosteroids on bone mineral density in older women with asthma or COPD: a registry-based cohort study

Arch Osteoporos. 2018 Oct 29;13(1):116

Less chaos in the prognosis of asthma-chronic obstructive lung disease overlap.

Lancet Respir Med. 2016 Jun;4(6):421-2

The association between previous and future severe exacerbations of chronic obstructive pulmonary disease: Updating the literature using robust statistical methodology.

Using robust statistical methodology that controlled for heterogeneity in exacerbation rates among individuals, we demonstrated potential causal associations among past and future severe exacerbations, albeit the magnitude of association was noticeably low...

Using robust statistical methodology that controlled for heterogeneity in exacerbation rates among individuals, we demonstrated...

Faculty of Pharmaceutical Sciences & UBC Division of Respiratory Medicine Respiratory Evaluation Sciences Program

Faculty of Pharmaceutical Sciences & UBC Division of Respiratory Medicine
Respiratory Evaluation Sciences Program